Weiping Lu

Reader

Telephone
+44 (0)131 451 3065
Email
w.lu@hw.ac.uk
Address
Room 2.12
David Brewster Building
Heriot-Watt University
Research

Main research interests in two areas:

In the area of Physics with Life Sciences Interface, we develop advanced computational methods for image processing and analysis and work with biologists and medical physicists to apply these techniques to fluorescence microscopy and ultrasound images. This includes a new image restoration method, called translation microscopy (TRAM), for super-resolution microscopy imaging. TRAM can improve the resolution of diffraction limited images from a confocal microscope to the level of the state of the art STED super-resolution microscope. We have been further developing new algorithms capable of detection and tracking of transport particles within biological live cells and microbubbles in contrast-enhanced ultrasound (CEUS) images.

In Atomic, Molecular and Nonlinear Optics, we study the nonlinear phenomena of cold atoms and molecules in novel optical fields. Our aim is to understand and exploit their collective dynamics arising from the nonlinear interactions for applications, such as deceleration of cold molecular beams.

Selected publications

Y. Liu and W. Lu, A robust iterative algorithm for image restoration, EURASIP Journal on Image and Video Processing, (2017) 2017:53. Link

R. S. Wilson, L. Yang., A. Dun, A. M. Smyth, R. R. Duncan, C. Rickman, & W. Lu, Automated single particle detection and tracking for large microscopy datasetsRoyal Society Open Science. 3, 5, 160225 (2016). Link

Z. Qiu, R. S. Wilson, Y. Liu, Y., Dun, A., Saleeb, R. S., Liu, D., Rickman, C., Frame, M., Duncan, R. & Lu, W. Translation Microscopy (TRAM) for super-resolution imagingNature Scientific Reports. 6, 19993 (2016).  Link

D. M. Kavanagh, A. M. Smyth, K. J. Martin, A. Dun, E. R. Brown, S. Gordon, K. J. Smillie, L. H. Chamberlain, R. S. Wilson, L. Yang, W. Lu, M. A. Cousin, C. Rickman, and R. R. Duncan. A molecular toggle after exocytosis sequesters the presynaptic syntaxin1a molecules involved in prior vesicle fusionNature Communications, 5:5774, 2014. Link

M. Smyth, L. Yang, K. J. Martin, C. Hamilton, W. Lu, M. A. Cousin, C. Rickman, and R. R. Duncan. Munc18-1 molecules move between membrane molecular depots distinct from vesicle docking sitesJournal of Biological Chemistry, 288(7): 5102-5113, 2013.Link

 

L. Yang, Z. Qiu, A. H. Greenaway, W. Lu,A New Framework for Particle Detection in Low SNR Fluorescence Live-cell Images and Its Application for Improved Particle TrackingIEEE transactions on biomedical engineering, 59(7): 2040-2050, 2012. Link

 

Z. Qiu; L. Yang, W. Lu, A New Feature-Preserving Nonlinear Anisotropic Diffusion for Denoising Images Containing Blobs and RidgesPattern recognition letters, 33, 319 (2012). Link

 

L. Yang, A. Dun, K. J. Martin, Z. Qiu, Z., A. Dunn, G. J. Lord, W. Lu, R. R. Duncan, & C. Rickman. Secretory vesicles are preferentially targeted to areas of low molecular SNARE densityPLOS ONE. 7, 11, p. e49514 (2012). Link

 

Z. Lan, A. Celi, W. Lu, P. Ohberg & M. Lewenstein. Tunable multiple layered Dirac cones in optical latticesPhysical Review Letters. 107, 25, p. 253001-253005 5 p. (2011). Link

 

R. Parton, R. Hamilton, G. Ball, L. Yang, F. Cullen, W. Lu, H. Ohkura and I. Davis, A Par-1 dependent graded bias in microtubule orientation establishes cell polarity in the Drosophila oocyteJournal of Cell Biology194, 121 (2011). Link

Biography

Weiping joined Heriot-Watt in 1988 as a China Research Fellow under the Royal Society and Chinese Academy Exchange Programme. He obtained his PhD from Heriot-Watt in 1991 on nonlinear dynamics and chaos in optical systems and then worked as a postdoc in the same subject area. He received the 67th Award of the Makdougall-Brisbane Prize in1998 by the Royal Society of Edinburgh for his contributions to this subject. He was appointed a Lecturer in 1997 and is now a Reader in the School of Engineering and Physical Sciences.