Dr Ruaraidh McIntosh
- +44 (0)131 451 8039
William Perkin Building
Roles and responsibilities
- Deputy Head of Molecular Chemistry
- ICS Representative, EPS Athena SWAN Committee
- Programme Director, Chemistry with a Year in North America
Supramolecular Chemistry and Catalysis
We aim to exploit the principles of supramolecular chemistry to construct assemblies which have application in a number of different fields.
1. Supramolecular catalysis
A depleting and increasingly unstable supply has resulted in the polymer industry seeking alternatives to petrochemical feedstocks. A potential solution to this problem is to look at developing new polymers which can be derived from sustainable resources. Utilising the principles of supramolecular chemistry we seek to create catalysts for this purpose which are capable of controlling selectivity and can function without the use of organic solvents.
Figure 1.Titanium cluster which shows activity towards the polymerisation of lactide.
Development of switchable micelles
The efficacy of many drugs is hindered by their poor solubility in water and therefore their ability to be absorbed into the body is reduced. We create amphiphilic molecular capsules which can contain the hydrophobic drug within its own hydrophobic core whilst the hydrophilic exterior of the capsule will aid solubility in the body. These simple molecules are capable of forming micelles activated by simple non-toxic triggers and can cycle between the two states multiple times
Up-to-date publications are listed on this research profile.