PhD

Associate Professor

Telephone
+44 (0)131 451 3148
Email
s.yarwood@hw.ac.uk
Address
Room 3.07
William Perkin Building
Heriot-Watt University
Stephen Yarwood
Roles and responsibilities

Visit my Research Page

2016 - present  Associate Professor, School of Life Sciences, Heriot-Watt University, Edinburgh Campus

Professional and Learned Societies:

2016 - present Local Ambassador for the Biochemical Society at Heriot-Watt University

2015 - present Journal of Cell Signalling – Editorial Board

2013 - present Fellow of the Higher Education Academy

2012 - 2014 Biochemical Society - Member of Council

2011 - present Biochemical Journal – Editorial Advisor

2011 - 2013 Biochemical Society - Chair of the Signal Transduction Theme Panel

2008 - 2011 Biochemical Society - "Theme Panel V: Signal Transduction" committee member

1999 - 2001 Human Frontiers Science Program Fellow

1993 - present Biochemical Society – Member

Research

Recent Grants:

Use of Affimer Technology to discriminate between Agonist- and Antagonist-induced Conformational Changes in the Cyclic-nucleotide Binding Domain (CNBD) Protein, EPAC1, Medical Research Scotland PhD Studentship (2015-2019), £109,784, Principle Investigator

Identification of Small Molecule Agonists – European Lead Factory (2015-2018), contract worth £300,000, Program Owner

Regulation of anti-inflammatory gene expression in vascular endothelial cells by EPAC1 – British Heart Foundation (2015-2018), £220,852, Principle Investigator

The role of insulin-dependent signalling pathways in the control of Mesenchymal stem cell differentiation towards bone and fat - Tenovus-Scotland (2014 – 2016), £10,000, Principle Investigator

The sensitive assessment of the activity of cellular signalling pathways regulating insulin action and the cardiovascular complications of diabetes Diabetes UK (2011 – 2014), £94,941, Co-Investigator

Identification of small molecule activators of EPAC1 to serve as novel anti-inflammatory agents in vascular endothelial cells - Scottish Universities Life Sciences Alliance (2011 – 2012), contract worth £20,000, Programme Owner

The Role of EPAC1-regulated Protein Kinase C Isoforms in Mediating C/EBPdelta -dependent, Anti-inflammatory Actions of Cyclic AMP in Vascular Endothelial Cells - British Heart Foundation (2010 – 2013), £220,852, Principle Investigator

EPAC1 and ERK-dependent activation of C/EBP transcription factors: a new cyclic AMP-activated anti-inflammatory gene expression module in vascular endothelial cells - British Heart Foundation (2009 – 2012), £245,576, Co-Investigator

Selected publications

Publications from Past 5 Years:

Parnell E, Koschinski A., Zaccolo M, Cameron RT, Baillie GS, Baillie GL, Porter A, McElroy SP and Yarwood SJ (2015) Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells. Biochim Biophys Acta 1853(7):1749-58

Parnell E, Palmer TM, Yarwood SJ. (2015) The future of EPAC-targeted therapies: agonism versus antagonism. Trends Pharmacol Sci. 36(4): 203-214

Parnell E, Smith BO, Yarwood SJ. (2015) The cAMP sensors, EPAC1 and EPAC2, display distinct subcellular distributions despite sharing a common nuclear pore localisation signal. Cell Signal. 27(5):989-96.

Wiejak J, Dunlop J, Yarwood SJ. (2014) The role of c-Jun in controlling the EPAC1-dependent induction of the SOCS3 gene in HUVECs. FEBS Lett. 588:1556-61.

Wiejak J, Dunlop J, Mackay SP, Yarwood SJ. (2013) Flavanoids Induce Expression of the Suppressor of Cytokine Signalling 3 (SOCS3) Gene and Suppress IL6- Activated Signal Transducer and Activator of Transcription 3 (STAT3) Activation in Vascular Endothelial Cells. Biochem J. 454(2):283-93.

Wiejak J, Tsimbouri PM, Herzyk P, Dalby MJ, Hamilton G, Yarwood SJ. (2013) Genomic analysis of the role of transcription factor C/EBPδ in the regulation of cell behaviour on nanometric grooves. Biomaterials 4(8):1967-79.

Wiejak J, Dunlop J, Stoyle C, Lappin G, McIlroy A, Pediani JD, Gao S, Yarwood SJ. (2012) The protein kinase C inhibitor, Ro-31-7459, is a potent activator of ERK and JNK MAP kinases in HUVECs and yet inhibits cyclic AMP-stimulated SOCS-3 gene induction through inactivation of the transcription factor c-Jun. Cell Signal. 24(8):1690-9.

Wiejak J, Dunlop J, Gao S, Borland G, Yarwood SJ. (2012) Extracellular signal-regulated kinase mitogen-activated protein kinase-dependent SOCS-3 gene induction requires c-Jun, signal transducer and activator of transcription 3, and specificity protein 3 transcription factors. Mol Pharmacol. 81(5):657-68.

Parnell E, Smith BO, Palmer TM, Terrin A, Zaccolo M, Yarwood SJ. (2012) Regulation of the inflammatory response of vascular endothelial cells by EPAC1. Br J Pharmacol. 166(2):434-46.

Bird RJ, Baillie GS, Yarwood SJ. (2010) Interaction with receptor for activated C-kinase 1 (RACK1) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase C. Biochem J. 432(1):207-16.

Biography

Previous Roles:

2008 - 2015 Senior Lecturer, Institute of Molecular, Cell and Systems Biology

Faculty of Medical, Veterinary and Life Sciences University of Glasgow, Scotland

1999 - 2008 Lecturer, Division of Biochemistry & Molecular Biology, Institute of Biomedical and Life Sciences (IBLS), University of Glasgow, Scotland.

1999 - 2001 Research Leave, Human Frontiers Science Program Research Fellow, Ontario Cancer Institute, Toronto, Canada.

1996 - 1999 Post-Doctoral Fellow, Laboratory of Professor Miles D. Houslay, University of Glasgow, Scotland.

Higher Education:

2004 - 2005 University of Glasgow, U.K., Postgraduate Certificate in Academic Practice

1993 - 1996 Hannah Research Institute, Ayr, Scotland, U.K., Ph.D. in Biochemistry.

1988 - 1992 University of Strathclyde, U.K., B.Sc. (Hons) Upper Second in Biochemistry

Awards:

1999 - 2001 Human Frontiers Science Program Fellowship

Further information

Recent Invited Talks:

Yorkhill Research Day, Glasgow 2015

Bone Marrow Adiposity meeting, Lille, France 2015

British Society for Paediatric Endocrinology and Diabetes (BSPED), Winchester 2014

Gordon Research Conference, New England, USA 2014

British Endocrinology Society, Liverpool 2014

Physiology Society Sponsored Lecture, Department of Physiology, University of Liverpool 2013

Targeting Cyclic AMP Signalling to Combat Cardiovascular Diseases, London 2013

British Pharmacology Society, Cyclic AMP meeting, London 2011

Signalling 2011: A Biochemical Society Centenary Celebration, Edinburgh 2011