Prof. Vicki Stone BSc PhD ILTM FIBiol CBiol
Roles and responsibilities
I am Professor of Toxicology and Director of Nano-Safety Research Group in the School of Life Sciences.
My responsibilities include:
- Member of SnIRC (Safety of nanomaterials Interdisciplinary Research Collaboration) that includes Heriot-Watt University, Edinburgh Napier University, the Institute of Occupational Medicine (IOM), the University of Edinburgh and Central Sciences Laboratory.
- Director of Toxicology for SAFENANO, a facility to support the risk, exposure and hazard needs of nanotechnology industries.
- Editor-in-chief of the journal Nanotoxicology (impact factor 5.77).
- PhD supervision and conducting numerous PhD vivas at universities throughout Europe.
- EC FP7 funding – NanoImpactNet (€26,870), ENPRA (€191,537), InLiveTox (€430,107), Qnano (€200,000)
- EPSRC – High performance carbon nanotubes (£200,000)
- The Colt Foundation – Molecular mechanisms of nanoparticle induced toxicity (£189,372), Nanoparticle – protein interactions (£287,282)
- Daphne Jackson Fellowship - Adjuvant effects of nanoparticles (£50,560)
- Unilever - Ecotoxicology of nanoparticles (£52,500)
- US-UK (NERC) – Manufactured Nanomaterial Bioavailability and Environmental Exposure (NanoBee) (£180,000)
Recently completed projects
- NERC led JEHH programme – Human and environmental effects of nanoparticle exposure (£180,000)
- Defra – REFNANO, HARN, CELLPEN and EMERGNANO (all published online)
- EC FP7 – ENRHES
- EC FP6 – PARTICLE_RISK
Gaiser BK, Fernandes TF, Jepson MA, Lead JR, Tyler CR, Baalousha M, Biswas A, Britton GJ, Cole PA, Johnston BD, Ju-Nam Y, Rosenkranz P, Scown TM, Stone V. Interspecies comparisons on the uptake and toxicity of silver and cerium dioxide nanoparticles. Environ Toxicol Chem 2010. Accepted
Gaiser BK, Biswas A, Rosenkranz P, Jepson M, Lead JR, Stone V, Tyler CR, Fernandes TF. Effects of silver and cerium dioxide micro- and nano-sized particles on Daphnia magna. J Environ Monitor Accepted
Aschberger K, Johnston H, Stone V, Aitken R, Tran CL, Hankin S, Peters S, Christensen FM. Review of fullerene toxicity and exposure - appraisal of a human helath risk assessment, based on open literature. Regul Toxicol Pharm 2010;In press
Aschberger K, Johnston H., Stone V, Aitken R, Hankin S, Peters A, Tran CL, Christensen FM. Review of carbon nanotubes toxicity and exposure-appraisal of human health risk assessment based on open literature. Crit Rev Toxicol 2010; In press
Brandenberger C, Clift M, Vanhecke D, Muhlfeld C, Stone V, Gehr P, Rothen-Rutishauser B. Intracellular imaging of nanoparticles: Is it an elemental mistake to believe what you see? Part Fibre Toxicol 2010;In press
Bouwmeester H, Lynch I, Marvin HJP, Dawson K, Berges M, Braguer D, Byrne HJ, Casey A, Chambers, G, Clift M, Elia G, Fernandes T, Fjellsbo LB, Hatto P, Juillerat L, Klein C, Kreyling WG, Nickel C, Riedeker M, Stone V. Minimal Analytical characterisation of engineered nanomaterials needed for hazard assessment in biological matrices. Nanotoxicology, 2010: Early Online, 1-11
Brandenberger C, Brown D, Brownlee B, Clift M, Davidson AM, Hankin, SM, Rothen-Rutishauser B, Stone V, Varet J. Quantum dot cytoxicity in vitro: An investigation into the cytotoxic effects of a series of different surface chemistries and their core/shell materials. Nanotoxicology 2010: Early Online, 1-11
Christensen FM, Johnston H, Stone V, Aitken R, Hankin S, Peters S, Aschberger K. Nano-TiO2 - feasibility and challenges for human health risk assessment based on open literature. Nanotoxicology 2010;Early online:1-15
Brandenberger C, Clift M, Vanhecke D, Muhlfeld C, Stone V, Gehr P, Rothen-Rutishauser B. Intracellular imaging of nanoparticles: is it an elemental mistake to believe what you see? Part Fibre Toxicol 2010;7:15
Brown D, Dickson C, Duncan P, Al-Attili F, Stone V. Interaction between nanoparticles and cytokine proteins: impact on protein and particle functionality. Nanotechnology 2010;21(21):215104
Brown D, Donaldson K, Stone, V. Nuclear translocation of Nrf2 and expression of antioxidant defence genes in THP-1 cells exposed to carbon nanotubes. J Biomed Nanotechnology 2010, Vol 6, No3
Christensen FM, Johnston H, Stone V, Aitken R, Hankin S, Peters S, Aschberger K. Nano-silver - feasibility and challenges for human health risk assessment based on open literature. Nanotoxicology 2010;4(3):284-295
Clift M, Boyles M, Brown D, Stone V. An investigation into the potential for different surface-coated quantum dots to cause oxidative stress and affect macrophage cell signalling in vitro. Nanotoxicology 2010;4(2):139-149
Gomes EC, Stone V, Florida-James G. Investigating performance and lung function in a hot, humid and ozone-polluted environment. Eur J Appl Physiol 2010 September;110(1):199-205
Rothen-Rutishauser B, Brown DM, Piallier-Boyles M, Kinloch IA, Windle AH, Gehr P, Stone V. Relating the physicochemical characteristics and dispersion of multiwalled carbon nanotubes in different suspension media to their oxidative reactivity in vitro and inflammation in vivo. Nanotoxicology 2010 September;4:331-342
Clift M, Bhattacharjee S, Brown D, Stone V. The effects of serum on the toxicity of manufactured nanoparticles. Toxicol Lett August 2010
Foucaud L, Goulaouic S, Bennasroune A, Laval-Gilly P, Brown D, Stone V, Falla J. Oxidative stress induction by nanoparticles in THP-1 cells with 4-HNE production: Stress biomarker or oxidative stress signalling molecule? Toxicol In Vitro 2010 July 16
Johnston HJ, Hutchison G, Christensen FM, Peters S, Hankin S, Aschberger K, Stone V. A critical review of the biological mechanisms underlying the in vivo and in vitro toxicity of carbon nanotubes: The contribution of physico-chemical characteristics. Nanotoxicology 2010 June;4:207-246
Scown TM, Santos EM, Johnston BD, Gaiser B, Baalousha M, Mitov S, Lead JR, Stone V, Fernandes TF, Jepson M, van AR, Tyler CR. Effects of aqueous exposure to silver nanoparticles of different sizes in rainbow trout. Toxicol Sci 2010 June;115(2):521-534
Johnston HJ, Hutchison G, Christensen FM, Peters S, Hankin S, Stone V. A review of the in vivo and in vitro toxicity of silver and gold particulates: particle attributes and biological mechanisms responsible for the observed toxicity. Crit Rev Toxicol 2010 April;40(4):328-346
Johnston HJ, Hutchison G, Christensen FM, Aschberger K, Stone V. The biological mechanisms and physicochemical characteristics responsible for driving fullerene toxicity. Toxicol Sci 2010 April;114(2):162-182
Stone V, Nowack B, Baun A, van den BN, Kammer F, Dusinska M, Handy R, Hankin S, Hassellov M, Joner E, Fernandes TF. Nanomaterials for environmental studies: classification, reference material issues, and strategies for physico-chemical characterisation. Sci Total Environ 2010 March 1;408(7):1745-175
Hoek G, Boogaard H, Knol A, de HJ, Slottje P, Ayres JG, Borm P, Brunekreef B, Donaldson K, Forastiere F, Holgate S, Kreyling WG, Nemery B, Pekkanen J, Stone V, Wichmann HE, van der SJ. Concentration response functions for ultrafine particles and all-cause mortality and hospital admissions: results of a European expert panel elicitation. Environ Sci Technol 2010 January 1;44(1):476-482
Johnston HJ, Semmler-Behnke M, Brown DM, Kreyling W, Tran L, Stone V. Evaluating the uptake and intracellular fate of polystyrene nanoparticles by primary and hepatocyte cell lines in vitro. Toxicol Appl Pharm 2010 January 1;242(1):66-78
I graduated from the University of Leeds in 1991 with a 1st class honours degree in Physiology. At the University of Leeds I was the recipient the University of Leeds Centenary Medal.
My PhD was completed at Birmingham University in Toxicology in 1994 supervised by Prof Roger Coleman and Prof Kevin Chipman. While studying in Birmingham I was awarded the British Toxicology Society Young Investigator Award.
I provided expert advice on particle toxicology to the World Health Organisation, the Royal Society/Royal Academy of Engineering and to the Royal Commission.
I am a member of the Department of Health's Committee on the Medical Effects of Air Pollution (COMEAP), and in the past have worked as an executive member of the International Council on Nanotechnology (ICON) and Consultant to the Olympic Medical Association.
I have been an invited speaker at conferences in Australia (Perth and Sydney), Asia (Taiwan and Japan), USA (San Francisco, North Carolina, Florida, Miami) and Europe (Denmark, France, Spain, Germany, Italy, Switzerland).
Collaborators spread across Europe (more than 20 institutes through EU projects), USA (National Institute of Occupational Safety and Health, University of Rochester, Rice University) and Japan.
I am an expert advisory panel member for CEINT (Center for the Environmental Implications of Nanotechnology, Duke University, USA) and NANOTEST (EC FP7 funded project).
I have published over 100 research papers.
I am a member of the British Toxicology Society.
I am a grant reviewer for MRC, EPSRC, The Colt Foundation, the Swiss National Research Programme, The Austrian Research Council and others.